Ruba S. Darweesh. Ph.D.

 

Department of pharmaceutical Technology

Faculty of pharmacy
Jordan University of Science and Technology

 

P.O.Box 3030, Irbid - Jordan 22110, 
Phone: +962-2-7201000 Ext. 26821

 

Fax: +962-2-7201075

Email: rsdarweesh@just.edu.jo

rubadarweish@gmail.com

 

 

Education

Ph.D. in Pharmaceutical Sciences.

Aerosol Research Group, Department of Pharmaceutics

Virginia Commonwealth University, VA-USA.

(Aug. 2009-Dec 2013).

 

B.Sc. in Pharmacy- Excellent Evaluation with Honors.

Student status: on the university and school honor’s lists (all semesters).

Faculty of Pharmacy,

Jordan University of Science and Technology. Irbid-Jordan.

(Sep. 2002-Jan. 2007).

 

Experiences

-      Jordan University of Science and Technology. Irbid-Jordan

Assistant Dean

Department of pharmaceutical Technology, Faculty of pharmacy

(Sep 2022-Present)

 

-      Jordan University of Science and Technology. Irbid-Jordan

Associate professor

Department of pharmaceutical Technology, Faculty of pharmacy

(Aug 2021-Present)

 

-      Fellowship in Responsible Conduct of Research Irbid-Jordan

This fellowship is led by University of California San Diego (UCSD) in collaboration with Jordan University of Science and Technology (JUST); https://jordanrcrprogram.com/

(July 2017-Nov 2018)

 

-      Visiting research scholar/Affiliate faculty member. VA-USA

Dr. Michael Hindle's research group/ ARG at VCU Pharmaceutical department, School of pharmacy. (July.01. 2016 –Sep. 17. 2016).

 

-      Jordan University of Science and Technology. Irbid-Jordan

Assistant professor

Department of pharmaceutical Technology, Faculty of pharmacy

(Feb. 2014 -July 2021).

 

-      Virginia Commonwealth University. VA-USA

Teaching Assistant

Pharmaceutical department, School of pharmacy.

(Jan. 2012 -May 2012).

 

-      Jordan University of Science and Technology. Irbid - Jordan

Teaching Assistant

Pharmaceutical Technology department, Faculty of pharmacy.

(Sep. 2008 – Jul. 2009).

 

-      Tabuk Pharmaceutical Mfg. Co. Amman-Jordan.

Regulatory Affairs officer (Algeria/North Africa region)

(May 2007 – Jul. 2008).

 

Teaching experience:

-      Graduate courses:

 

Phar951: Advanced Biopharmaceutics and Pharmacokinetics

(PhD students)

Phar 756: Advanced Biopharmaceutics and Pharmacokinetics

(Masters students)

 

-      Undergraduate courses:

 

Phar456: Biopharmaceutics and Pharmacokinetics

(Pharmacy and Pharm. D. Students)

Phar553: Clinical Pharmacokinetics

(Pharm. D. Students)

Phar351: Pharmaceutics

(Pharmacy and Pharm. D. Students)

 

Conferences, workshops, and training Courses

 

 

-      The 4th MENA Regulatory Conference on Bioequivalence, Biowaivers, Bioanalysis And Dissolution (RBBBD) in Jordan. Irbid, Jordan (Sep 19th and 20th 2022)

-      The 4th International Conference on Ethics in Jordan. Irbid, Jordan (Nov. 05. 2019; member of the organizer committee).

-      JUST international Pharmacy conference, the 4th conference for faculties of Pharmacy in Jordan. Irbid, Jordan (Aug. 02-04. 2017; member of the organizer committee).

-      The 2nd international conference on ethics in Jordan: Clinical trials. Irbid, Jordan (Aug. 03 and 04. 2017; member of the organizer committee).

-      Applied Statistics for Life and Social Sciences using R. Academic Development and Quality Assurance Center. Irbid, Jordan. (Jan. 31. 2015 -  Feb. 01. 2016).

-      E-Learning: Open Educational Resources (OER). Academic Development and Quality Assurance Center. Irbid, Jordan. (Sep.13-14. 2015).

-      Respiratory Drug Delivery 2014. Fajardo, Puerto Rico. (May. 04-08. 2014).

-      AAPS annual meeting and exposition 2012. McCormick Place, Chicago, IL-USA. (Oct. 14–18. 2012).

-      Respiratory Drug Delivery 2012. JW Marriott Desert Resort & Spa, Phoenix, AZ-USA (May 13-17. 2012). 

-      Therapeutic equivalence: Regulatory and scientific issues in drug product development. Jonah Larrick Student Center, Virginia Commonwealth university, Richmond, VA-USA (Apr. 18. 2012).

-      AAPS annual meeting and exposition 2011. Walter E. Washington convention center, Washington, DC-USA (Oct. 23-27. 2011).

-      19th Inhalation aerosol technology workshop. Baltimore, MD-USA (Jun.14-16. 2010) with the laboratory session (Jun. 17. 2010).

-      Advanced PK/PD modeling workshop. Richmond, VA-USA (Jun. 7-10. 2010)

-      Certified Project Manager (CPM). Modern Manager Consulting Co. Amman-Jordan. (Feb. 23. 2008 –Mar. 1. 2008).

-      Strategies for time management excellence. Coaching Moments for Management Consultation LTD. Co. Amman-Jordan ( Jul. 30 –Aug. 1. 2007). 

-      Decision making, Problem solving, Creative thinking, Communication skills workshops. Jordan university of Science and Technology. Irbid-Jordan (Mar. 2006).

-      Stress and time management workshop. Jordan university of Science and Technology. Irbid-Jordan (Mar. 2006).

 

Awards and Recognitions

-      2012 AstraZeneca travel award in recognition of research presented in AAPS annual meeting and exposition 2012. McCormick Place, Chicago, IL-USA. (Oct. 14–18. 2012).

 

-      Aradigm Corporation made a press release in recognition of research presented in AAPS annual meeting and exposition 2012, “Virginia Commonwealth University Scientists Report Anti-Inflammatory Effect of Aradigm's Inhaled Liposomal Ciprofloxacin” (Oct.16. 2012).

 

Website: https://investor.aradigm.com/releasedetail.cfm?releaseid=713676

 

-      Phi Kappa Phi award 2011, “Phi Kappa Phi is collegiate honor society for all academic disciplines that recognizes graduate students in the top 10% of their class.” (2011)

 

-      Thakker award 2010 “In recognition of demonstrated excellence in research in the department of pharmaceutics”. School of pharmacy, Virginia Commonwealth University, VA-USA. (Oct.15. 2010).

 

-      Jordan University of Science and Technology full scholarship to pursue doctorate degree in Virginia Commonwealth University. (Sep 2009-Dec 2013).

 

-      King Abdallah II center for excellence full scholarship in recognition of academic excellence that covers all tuitions of Jordan University of Science and Technology- Faculty of pharmacy. (Jan 2003-Dec 2006).

 

Research funds and support:

 

1. 329-2016 (Principal Investigator): Jordan University of Science and Technology, 2016-2018: "Effect of Grape Seed and its Co-administration with Green Tea on the Pharmacokinetics of Imatinib".

2. 227-2016 (Co-Investigator): Jordan University of Science and Technology, 2016-2018 “Effect of Green Tea Extract on the Pharmacokinetics of Imatinib”.

 

3. 080-2017 (Principal investigator): Jordan University of Science and Technology, 2017-2018: “In Vitro Evaluation of Anti-Angiogenic Effects of Gold Nanoparticles: The Role of Shape, Size and Surface Charge”.

 

4. 335-2017 (Co-Investigator): Jordan University of Science and Technology, 2017-2018 “Effect of Piperine on The Pharmacokinetics of Warfarin in Rats”

 

5. 424-2017 (Principal investigator): Jordan University of Science and Technology, 2017-2018 “Effect of Cannabidiol on the Pharmacokinetics of Carbamazepine”.

 

6. 427-2017 (Principal investigator): Jordan University of Science and Technology, 2017-2018: “Realistic Physical Nasal Airway Model for the Assessment of Transepithelial Transport of Ciprofloxacin”.

 

7. 321-2019 (Principal investigator): Jordan University of Science and Technology, 2019-2021: Characterization of the Transport and Uptake Kinetics of Sumatriptan Using Intranasal Epithelial In Vitro Model”.

 

8. 715-2019 (Principal investigator): Jordan University of Science and Technology, 2019-2021: “The pharmacokinetics of darunavir in a combined oral formulation with ritonavir in vivo in rats”.

 

 

Publications:

-      Al-Nemrawi, N. K., Altawabeyeh, R. M., & Darweesh, R. S. (2022). Preparation and Characterization of Docetaxel-PLGA Nanoparticles Coated with Folic Acid-chitosan Conjugate for Cancer Treatment. J Pharm Sci, 111(2), 485-494. https://doi.org/10.1016/j.xphs.2021.10.034

-      Qandil, A. M., R. S. Darweesh and A. M. Al-Ghananeem (2021). "The Case for Authentic Student Assessment in Distance Digital Pharmacy Education." MedEdPublish 10.

 

-       Darweesh RS, El-Elimat T, Zayed A, Khamis, T. N. et al. "The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats." BMC Pharmacol Toxicol. 2020; 21(1): 77.

 

-      Al Sharie AH, El-Elimat T, Darweesh RS, et al. Green synthesis of zinc oxide nanoflowers using Hypericum triquetrifolium extract: characterization, antibacterial activity and cytotoxicity against lung cancer A549 cells. Applied Organometallic Chemistry. 2020;34(8):e5667.

 

-      Zayed A, Babaresh WM, Darweesh RS, El-Elimat T. Simultaneous determination of warfarin and 7-hydroxywarfarin in rat plasma by HPLC-FLD. Acta pharmaceutica. 2020;70(3):343-357.

 

-      Darweesh RS, Khamis TN, El-Elimat T. The effect of cannabidiol on the pharmacokinetics of carbamazepine in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2020;393(10):1871-1886.

 

-      Zayed A, Babaresh WM, Darweesh RS, El-Elimat T, Hawamdeh SS. Piperine Alters the Pharmacokinetics and Anticoagulation of Warfarin in Rats. Journal of experimental pharmacology. 2020;12:169-179.

 

-      Darweesh RS, Ayoub NM, Nazzal S. Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications. International journal of nanomedicine. 2019;14:7643-7663.

-       

-      Darweesh, RS and M. Sakagami, In vitro lung epithelial cell transport and anti-interleukin-8 releasing activity of liposomal ciprofloxacin. Eur J Pharm Sci, 2018. 115: p. 68-76.

 

-      Al-Keilani MS, Alsmadi DH, Darweesh RS, Alzoubi KH, Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol, 2018. 10: p. 23-29.

 

-      Azimi M, Darweesh RS, Hindle M, Farkas DR, Golshahi L, Sakagami M and Longest PW. (2017) “The Use of a Physically Realistic Nasal Airway Model for the Assessment of In Vitro Transepithelial Transport of Nasally Administered Drugs”. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 30(3): A-19.

 

-      AlKeilani M, Darweesh RS “Sodium phenylbutyrate has an antineoplastic effect and enhances the cytotoxicity of 5-fluorouracil and irinotecan in colorectal cancer cell lines”. Cancer Research 77 (13 Supplement): 1188-1188·July 2017. DOI: 10.1158/1538-7445.AM 2017-1188.

 

-      Wei X, Kaviratna A, Darweesh RS, Longest PW, Hindle M. (2016)“Aerosol Performance and Stability Characteristics of Spray-Dried Tobramycin Excipient Enhanced Growth Inhalation Powder Formulations” Drug Delivery to the Lungs 27, 2016, Edinburgh, Scotland.

 

-      Darweesh RS, Sakagami. M. (2014). "In Vitro Inhibitory Activities of Liposomal Ciprofloxacin Against Lipopolysaccharide (LPS)-induced IL-8 Release from the Calu-3 Cells." Respiratory Drug Delivery 3: 747-750.

 

-      Darweesh RS, Sakagami. M. (2014). "Exploring Mechanisms of Absorptive Transport for Liposomal Ciprofloxacin Using the Calu-3 Cell Monolayers." Respiratory Drug Delivery 3: 751-754.

 

-      Sakagami. M., Arora-Lakhani D., Saluja B., Darweesh RS. (2013) “Getting To The Receptors: Impact of Aerosol Particle Dissolution, Drug Release And Cellular Uptake” Journal of Aerosol Medicine and Pulmonary Drug Delivery. 26(2): A10.

 

Posters and oral presentations

 

-      Poster presentation: Al-Keilani MS, Darweesh RS. Abstract 1188: Sodium phenylbutyrate has an antineoplastic effect and enhances the cytotoxicity of 5-fluorouracil and irinotecan in colorectal cancer cell lines. Cancer Research. 2017;77(13 Supplement):1188.

-      Poster presentation: AlTarifi A, Darweesh RS “ Effects of Waterpipe Water on Rewarding, Antinociceptive, and Locomotor Activity in Rats” AAAS “American Association for the Advancement of Science” Annual Meeting 2017. Hynes Convention Center, Boston, USA. (Feb. 16-20. 2017)

-      Poster presentation “ In Vitro Inhibitory Activities of Liposomal Ciprofloxacin Against Lipopolysaccharide (LPS)-induced IL-8 Release from the Calu-3 Cells.” Respiratory Drug Delivery 2014. El Conquistador Resort in Fajardo, Puerto Rico (May. 05-06. 2014)

-      Poster presentation “ Exploring Mechanisms of Absorptive Transport for Liposomal Ciprofloxacin Using the Calu-3 Cell Monolayers.” Respiratory Drug Delivery 2014. El Conquistador Resort in Fajardo, Puerto Rico (May. 05-06. 2014)

-      Research seminar “In Vitro Assessments of Lung Epithelial Anti-inflammation for Liposomal Ciprofloxacin: a Comparison with Unformulated Ciprofloxacin” Research Seminars in Drug Development (PCEU690). School of Pharmacy, Virginia Commonwealth University, Richmond, VA-USA (Feb. 26. 2013).

 

-      Poster presentation “In Vitro Assessments of Lung Epithelial Anti-inflammation for Liposomal Ciprofloxacin: a Comparison with Unformulated Ciprofloxacin”  2012 AAPS Annual Meeting and Exposition. McCormick Place, Chicago, IL-USA (Oct. 14–18. 2012).

 

-      Poster presentation “In Vitro Assessments of Lung Epithelial Anti-inflammation for Liposomal Ciprofloxacin: a Comparison with Unformulated Ciprofloxacin”  School of Pharmacy 15th Annual Pharmaceutical Sciences Research and Career Day. Virginia Commonwealth University, Richmond, VA-USA (Oct. 12. 2012).

-      Poster presentation Transport of Liposomal Ciprofloxacin across the Calu-3 Cell Monolayers: Transepithelial Electrical Resistance-dependent Transport” 2011 AAPS Annual Meeting and Exposition, Walter E. Washington convention center, Washington, DC-USA (Oct. 23-27. 2011).

 

-      Poster presentation Transport of Liposomal Ciprofloxacin across the Calu-3 Cell Monolayers: Transepithelial Electrical Resistance-dependent Transport” School of Pharmacy 14th Annual Pharmaceutical Sciences Research and Career Day. Virginia Commonwealth University, Richmond, VA-USA (Oct. 08. 2011).

-      Research seminar Transport of Ciprofloxacin and Liposomal Ciprofloxacin across the Calu-3 Cell Monolayers  Research Seminars in Drug Development (PCEU690). School of Pharmacy, Virginia Commonwealth University, Richmond, VA-USA (Feb. 22. 2011).

-      Poster presentation  Transport of Liposomal Ciprofloxacin across the Calu-3 Cell MonolayersSchool of Pharmacy 13th Annual Pharmaceutical Sciences Research and Career Day. Virginia Commonwealth University, Richmond, VA-USA (Oct. 08. 2010).

 

Memberships

-      American Association of Pharmaceutical scientists (AAPS). (Sep. 2010-Dec 2015).

-      Graduate Student Association & VCU/AAPS Student Chapter, school of pharmacy, Virginia Commonwealth University, VA-USA. (2009-2013).

-      The honor society of Phi Kappa Phi. (Nov. 2010-Nov. 2011).

-      Jordan Pharmaceutical Association, Amman-Jordan (2008-Present).

 

 

References

 

Sayer Alazzam, Ph.D. 

Professor

Dean of Faculty of pharmacy
Jordan University of Science and Technology

P.O.Box 3030, Irbid - Jordan 22110, 
Phone: +962-2-7201000   Ext. 23233
Fax: +962-2-7201075

Email: khalzoubi@just.edu.jo 

 

Michael Hindle, Ph.D.

Peter R. Byron Distinguished Professor 
Professor
 
School of Pharmacy - Department of Pharmaceutics 
410 N 12th
 Street 
P.O. Box 980533
 
Richmond, VA 23298-0533

Phone: (804) 828-6497
Fax: (804) 828-8359
Email: mhindle@vcu.edu

 

Masahiro Sakagami , Ph.D. 
Professor.

School of Pharmacy - Department of Pharmaceutics 
410 N 12th
 Street 
P.O. Box 980533
 
Richmond, VA 23298-0533

Phone: (804) 828-2014
Fax: (804) 828-8359
Email: msakagam@vcu.edu

 

Jurgen Venitz , M.D., Ph.D. 
Professor
School of Pharmacy -
Department of Pharmaceutics 
410 N 12th Street 
P.O. Box 980533
 
Richmond, VA 23298-0533

Phone: (804) 828-6249
Fax: (804) 828-8359
Email: jvenitz@vcu.edu