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qosay ali al-balas
• Department of Medicinal Chemistry and Pharmacognosy - Faculty Member

  • Ph.D. of Medicinal Chemistry from University of Strathclyde, 2008
  • Msc. of Pharmacy from Jordan University of Science and Technology, 2004
  • Bsc. of Pharmacy from Jordan University of Science and Technology, 2000

    Publications
  • Qosay A. Al-Balas, "Identification of 2-aminothiazole-4-carboxylate derivatives active aganist Mycobacterium tuberculosis H37Rv and the B-ketoacyl-ACP synthase mtFabH," PLoS ONE, vol. 4, no. 5, pp. 1-9, 2009
  • Al-Balas Q, Hassan M, Al-Oudat B, Alzoubi H, Mhaidat N, Almaaytah A , "Generation of the first structure-based pharmacophore model containing a selective "zinc binding group" feature to identify potential glyoxalase-1 inhibitors," Molecules, vol. 17, no. 12, pp. 13740-13758, 2012
  • Mhaidat NM, Qandil AM, Al-Balas QA, Hassan MA, Jaradat SA, Matalkah AM,, "Methoxyphenylcipro induces antitumor activity in human cancer cells," Arch Pharm Res, vol. 36, no. 8, pp. 1023-1028, 2013
  • Ammar Almaaytah, Shadi Tarazi, Nizar Mhaidat, Qosay Al-Balas, Tareq Mukattash, "Mauriporin, a Novel Cationic ?-Helical Peptide with Selective Cytotoxic Activity Against Prostate Cancer Cell Lines from the Venom of the Scorpion Androctonus mauritanicus ," International Journal of Peptide Research and Therapeutics, vol. 19, no. 4, pp. 281-293, 2013
  • Al-Balas QA, Amawi HA, Hassan MA, Qandil AM, Almaaytah AM, Mhaidat NM., "Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure - Based Pharmacophore Techniques," Pharmaceuticals, vol. 6, no. 6, pp. 700-715, 2013
  • Qosay Al-Balas, Mohammad Hassan, Nizar Mhaidat, Ammar Almaaytah, "In Silico Identification of Novel Leukotriene A 4 Hydrolase Inhibitors as Potential Anti - Inflammatory Agents," Jordan Journal of Chemistry, vol. 8, no. 3, pp. 199-211, 2013
  • Almaaytah A, Albalas Q , "Scorpion venom peptides with no disulfide bridges: a review," Peptides, vol. 51, no. , pp. 35-45, 2014
  • Al-Balas QA, Sowaileh MF, Hassan MA, Qandil AM, Alzoubi KH, Mhaidat NM, Almaaytah AM, Khabour OF. , "Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme," Drug Des Devel Ther, vol. 16, no. 8, pp. 129-163, 2014
  • Ammar Almaaytah , Shadi Tarazi, Fawzi Alsheyab, Qosay Al-Balas, Tareq Mukattash , "Antimicrobial and Antibiofilm Activity of Mauriporin, a Multifunctional Scorpion Venom Peptide," International Journal of Peptide Research and Therapeutics, vol. 20, no. 4, pp. 397-408, 2014
  • Almaaytah A, Tarazi S, Abu-Alhaijaa A, Altall Y, Alshar'i N, Bodoor K, Al-Balas Q. , "Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1," Pharmaceuticals, vol. 7, no. 5, pp. 502-516, 2014
  • Qandil AM, Al-Zoubi LO, Al-Bakri AG, Amawi HA, Al-Balas QA, Alkatheri AM, Albekairy AM , "Synthesis, Antibacterial Evaluation and QSAR of ?-Substituted-N4-Acetamides of Ciprofloxacin and Norfloxacin," Antibiotics, vol. 3, no. 3, pp. 244-269, 2014
  • Alzweiri M1, Al-Balas Q, Al-Hiari Y. , "Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III," J Enzyme Inhib Med Chem, vol. 30, no. 3, pp. 420-429, 2015
  • Mhaidat NM, Al-Wedyan TJ, Alzoubi KH, Al-Efan QM, Al-Azzam SI, Balas QA, Bataineh ZA. , "Measuring quality of life among colorectal cancer patients in Jordan.," J Palliat Care., vol. 30, no. 3, pp. 133-140,
  • Mhaidat NM, Alzoubi KH, Khabour OF, Banihani MN, Al-Balas QA, Swaidan S. , "GRP78 regulates sensitivity of human colorectal cancer cells to DNA targeting agents.," Cytotechnology, vol. 68, no. 3, pp. 459-467, 2016
  • Ammar Almaaytah, Shadi Tarazi, Mohammad Al-Fandi, Ahmad Abuilhaija, Nizar Al-shar’I, Qosay Al-Balas, Aymen Abu-Awad , "The Design and Functional Characterization of the Antimicrobial and Antibiofilm Activities of BMAP27-Melittin, a Rationally Designed Hybrid Peptide," Int J Pept Res Ther, vol. 21, no. , pp. 165-177, 2015
  • Nizar A. Al-Shar’I, Mohammad Hassan, Qosay Al-Balas, Ammar Almaaytah , "Identification of Possible Glyoxalase II Inhibitors as Anticancer Agents by a Customized 3D Structure-Based Pharmacophore Model," Jordan Journal of Pharmaceutical Sciences, vol. 8, no. 2, pp. 83-103, 2015
  • "A3, a Scorpion Venom Derived Peptide Analogue with Potent Antimicrobial and Potential Antibiofilm Activity against Clinical Isolates of Multi-Drug Resistant Gram Positive Bacteria", Molecules
  • "An Ethical Roadmap for Prioritizing Medical Resources Within Muslim Societies During the COVID?19 Pandemic", Journal of Religion and Health
  • "Biological activities and phenolic contents of Argania spinosa L (Sapotaceae) leaf extract", Tropical Journal of Pharmaceutical Research
  • "Carnosine to Combat Novel Coronavirus (nCoV): Molecular Docking and Modeling to Cocrystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein", Molecules
  • "Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents", Computational Biology and Chemistry
  • "Combined High Throughput Screening with QSAR Analysis Unravelling Potential Glyoxalase-I Inhibitors ", Current Computer-Aided Drug Design
  • "Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase-I inhibitors", Drug Development Research
  • "Computational fragment-based drug design of potential Glo-I inhibitors", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • "Computational medicinal chemistry role in clinical pharmacy education: Ingavirin for coronavirus disease 2019 (COVID-19) discovery model", Pharmacy Practice
  • "Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors", Drug Design, Development and Therapy
  • "Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents", Bioorganic & Medicinal Chemistry
  • "Design, synthesis and biological evaluation of potent thiazolidinedione salicylic acid inhibitors against glyoxalase-I as potential anticancer agents", Medicinal Chemistry Research
  • "Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators", Drug Design, Development and Therapy
  • "Development of Novel Ultrashort Antimicrobial Peptide Nanoparticles with Potent Antimicrobial and Antibiofilm Activities against Multidrug Resistant Bacteria", Drug Design, Development and Therapy
  • "Development of analytical methods GC-MS vs LC-UV for the serum monitoring of an inflammatory glycotoxin (methylglyoxal): A new biomarker of bovine hepatobiliary distomatosis", Biochimie
  • "Development of novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial and antibiofilm activities against multidrug-resistant bacteria", Drug Design, Development and Therapy
  • "Discovery of a Nanomolar Inhibitor of the Human Glyoxalase-I Enzyme Using Structure-Based Poly-pharmacophore Modelling and Molecular Docking", Journal of Computer-Aided Molecular Design
  • "Discovery of a nanomolar glyoxalase-I inhibitor using integrated ligand-based pharmacophore modeling and molecular docking", Medicinal Chemistry Research
  • "Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold", Acta Pharmaceutica
  • "Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides", Infection and Drug Resistance
  • "Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking", Molecules
  • "Identification of the first "two digit nano-molar" inhibitors of the human glyoxalase-I enzyme as potential anticancer agents.", Medicinal Chemistry
  • "In Silico and In Vitro Investigation of Anti Helicobacter Activity of Selected Phytochemicals", Journal of Pharmacy and Bioallied Sciences
  • "In vivo antimicrobial activity of the hybrid peptide H4: a follow-up study", Infection and Drug Resistance
  • "Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT?P) for Optimal Intelligence and Other Non?Disease?Related Socially Desirable Traits", Journal of Bioethical Inquiry
  • "Lead Optimization and Biological Evaluation of Diazenylbenzenesulfonamides Inhibitors Against Glyoxalase-I Enzyme as Potential Anticancer Agents", Bioorganic Chemistry
  • "Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study", Molecules
  • "Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends", Current Pharmaceutical Design
  • "Molecular docking and dynamic studies of a potential therapeutic target inhibiting glyoxalase system: Metabolic action of the 3, 3 ?- [3- (5-chloro-2-hydroxyphenyl) -3-oxopropane-1, 1-diyl] - Bis-4-hydroxycoumarin leads overexpression of the intracellular level of methylglyoxal and induction of a pro-apoptotic phenomenon in a hepatocellular carcinoma model", Chemico-Biological Interactions
  • "Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors", Molecules
  • "Novel Thiazole Carboxylic Acid Derivatives Possessing a ?Zinc Binding Feature? as Potential Human Glyoxalase-I Inhibitors", Letters in Drug Design & Discovery
  • "Physicochemical characterization and determination of chloramphenicol residues and heavy metals in Algerian honeys", Environmental Science and Pollution Research
  • "Recent Advances in Glyoxalase-I Inhibition", Mini-Reviews in Medicinal Chemistry
  • "Scorpion venom peptides with no disulfide bridges: A review", Peptides
  • "Structural optimization and biological evaluation of quinoline/ naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates", MEDICINAL CHEMISTRY RESEARCH
  • "Synthesis, molecular docking and evaluation of hypolipidemic activities of novel benzophenonecarboxamide derivatives", Indian Journal of Chemistry -Section B (IJC-B)
  • "The Ethics of Gene Editing from an Islamic Perspective: A Focus on the Recent Gene Editing of the Chinese Twins", Science and Engineering Ethics
  • "The ethics of practicing defensive medicine in Jordan: a diagnostic study", BMC Med Ethics
  • "The practice of defensive medicine among Jordanian physicians: A cross sectional study", PLOS ONE
  • "Traditional Islamic approach can enrich CRISPR twins debate", Nature
  • "Unraveling Potential Glyoxalase-I Inhibitors Utilizing Structure-Based Drug Design Techniques", Advances and Applications in Bioinformatics and Chemistry
  • "Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment.", Molecular biology reports
  • Head of the Center, Pharmaceutical Research, Sep 2014 - Sep 2016
  • Deputy Head of Department, Department of Medicinal Chemistry and Pharmacognosy, Sep 2011 - Sep 2013
  • Assistant Dean, Faculty Of Pharmacy, Sep 2009 - Aug 2010
  • Faculty Member, Department of Medicinal Chemistry and Pharmacognosy, Aug 2008 - Present
  • Full-time Lecturer, Department of Medicinal Chemistry and Pharmacognosy, Jun 2008 - Aug 2008
  • Senior Herbal Analyst, Arab Pharmaceutical Manufacturing (APM) , Jordan, Jul 2003- Apr 2004
  • Pharmacist in Charge, Community Pharmacy , Jordan, Jun 2000- Jun 2003
  • ADVANCED DRUG DESIGN
  • ADVANCED MEDICINAL CHEMISTRY
  • ADVANCED ORGANIC SYNTHESIS
  • CHEMISTRY OF HETEROCYCLIC
  • CHROMATOGRAPHY
  • DRUG DESIGN
  • DRUG DESIGN AND SYNTHESIS
  • DRUG DESIGN AND SYRTHESIS
  • FOUNDATIONS OF BIOETHICS
  • ISLAMIC THEOLOGICAL AND RELIGIOUS ASPECTS OF BIOETHICS
  • MEDICINAL CHEMISTRY (1)
  • MEDICINAL CHEMISTRY (2)
  • MEDICINAL CHEMISTRY 2
  • MEDICINAL CHEMISTRY LAB
  • MEDICINAL CHEMISTRY( 3)
  • MEDICINAL CHEMISTRY( 4)
  • MEDICINAL CHEMISTRY(2)
  • MEDICINAL CHEMISTRY(3)
  • MOLECULAR MODELING AND COMPUTER-AIDED DRUG DESIGN
  • Medicinal Chemistry 1 (for Pharm D students)
  • Medicinal Chemistry 2 (for Pharm D students)
  • PHARMACEUTICAL PRACTICAL TRAINING
  • PHARMACEUTICAL ORGANIC CHEMISTRY
  • PHARMACOGNOSY AND PHYTOCHEMISTRY LAB ORATORY
  • RESEARCH METHODOLOGY
  • SELECTED TOPICS ( 1)
  • SELECTED TOPICS ( 2)
  • SELECTED TOPICS IN MEDICINAL CHEMISTRY
  • SEMINAR
  • SPECIAL TOPICS (C)
  • STEREOCHEMISTRY