Qosay Ali Al-Balas

JUST A-Z

qosay ali al-balas

• Department of Medicinal Chemistry and Pharmacognosy - Faculty Member

• Faculty Of Pharmacy - Dean

23543
P1L-1
Department of Medicinal Chemistry and Pharmacognosy
qabalas@just.edu.jo

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Ph.D. of Medicinal Chemistry from University of Strathclyde, 2008
Msc. of Pharmacy from Jordan University of Science and Technology, 2004
Bsc. of Pharmacy from Jordan University of Science and Technology, 2000

Publications

Qosay A. Al-Balas, "Identification of 2-aminothiazole-4-carboxylate derivatives active aganist Mycobacterium tuberculosis H37Rv and the B-ketoacyl-ACP synthase mtFabH," PLoS ONE, vol. 4, no. 5, pp. 1-9, 2009
Al-Balas Q, Hassan M, Al-Oudat B, Alzoubi H, Mhaidat N, Almaaytah A , "Generation of the first structure-based pharmacophore model containing a selective "zinc binding group" feature to identify potential glyoxalase-1 inhibitors," Molecules, vol. 17, no. 12, pp. 13740-13758, 2012
Mhaidat NM, Qandil AM, Al-Balas QA, Hassan MA, Jaradat SA, Matalkah AM,, "Methoxyphenylcipro induces antitumor activity in human cancer cells," Arch Pharm Res, vol. 36, no. 8, pp. 1023-1028, 2013
Ammar Almaaytah, Shadi Tarazi, Nizar Mhaidat, Qosay Al-Balas, Tareq Mukattash, "Mauriporin, a Novel Cationic ?-Helical Peptide with Selective Cytotoxic Activity Against Prostate Cancer Cell Lines from the Venom of the Scorpion Androctonus mauritanicus ," International Journal of Peptide Research and Therapeutics, vol. 19, no. 4, pp. 281-293, 2013
Al-Balas QA, Amawi HA, Hassan MA, Qandil AM, Almaaytah AM, Mhaidat NM., "Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure - Based Pharmacophore Techniques," Pharmaceuticals, vol. 6, no. 6, pp. 700-715, 2013
Qosay Al-Balas, Mohammad Hassan, Nizar Mhaidat, Ammar Almaaytah, "In Silico Identification of Novel Leukotriene A 4 Hydrolase Inhibitors as Potential Anti - Inflammatory Agents," Jordan Journal of Chemistry, vol. 8, no. 3, pp. 199-211, 2013
Almaaytah A, Albalas Q , "Scorpion venom peptides with no disulfide bridges: a review," Peptides, vol. 51, no. , pp. 35-45, 2014
Al-Balas QA, Sowaileh MF, Hassan MA, Qandil AM, Alzoubi KH, Mhaidat NM, Almaaytah AM, Khabour OF. , "Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme," Drug Des Devel Ther, vol. 16, no. 8, pp. 129-163, 2014
Ammar Almaaytah , Shadi Tarazi, Fawzi Alsheyab, Qosay Al-Balas, Tareq Mukattash , "Antimicrobial and Antibiofilm Activity of Mauriporin, a Multifunctional Scorpion Venom Peptide," International Journal of Peptide Research and Therapeutics, vol. 20, no. 4, pp. 397-408, 2014
Almaaytah A, Tarazi S, Abu-Alhaijaa A, Altall Y, Alshar'i N, Bodoor K, Al-Balas Q. , "Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1," Pharmaceuticals, vol. 7, no. 5, pp. 502-516, 2014
Qandil AM, Al-Zoubi LO, Al-Bakri AG, Amawi HA, Al-Balas QA, Alkatheri AM, Albekairy AM , "Synthesis, Antibacterial Evaluation and QSAR of ?-Substituted-N4-Acetamides of Ciprofloxacin and Norfloxacin," Antibiotics, vol. 3, no. 3, pp. 244-269, 2014
Alzweiri M1, Al-Balas Q, Al-Hiari Y. , "Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III," J Enzyme Inhib Med Chem, vol. 30, no. 3, pp. 420-429, 2015
Mhaidat NM, Al-Wedyan TJ, Alzoubi KH, Al-Efan QM, Al-Azzam SI, Balas QA, Bataineh ZA. , "Measuring quality of life among colorectal cancer patients in Jordan.," J Palliat Care., vol. 30, no. 3, pp. 133-140,
Mhaidat NM, Alzoubi KH, Khabour OF, Banihani MN, Al-Balas QA, Swaidan S. , "GRP78 regulates sensitivity of human colorectal cancer cells to DNA targeting agents.," Cytotechnology, vol. 68, no. 3, pp. 459-467, 2016
Ammar Almaaytah, Shadi Tarazi, Mohammad Al-Fandi, Ahmad Abuilhaija, Nizar Al-shar’I, Qosay Al-Balas, Aymen Abu-Awad , "The Design and Functional Characterization of the Antimicrobial and Antibiofilm Activities of BMAP27-Melittin, a Rationally Designed Hybrid Peptide," Int J Pept Res Ther, vol. 21, no. , pp. 165-177, 2015
Nizar A. Al-Shar’I, Mohammad Hassan, Qosay Al-Balas, Ammar Almaaytah , "Identification of Possible Glyoxalase II Inhibitors as Anticancer Agents by a Customized 3D Structure-Based Pharmacophore Model," Jordan Journal of Pharmaceutical Sciences, vol. 8, no. 2, pp. 83-103, 2015
"Design, synthesis and biological evaluation of potent thiazolidinedione salicylic acid inhibitors against glyoxalase-I as potential anticancer agents", Medicinal Chemistry Research

Banan Omar Abedullah Alomari, Lara Ishaq Issa Alfakhori, Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas

09/08/2024
"Structural optimization and biological evaluation of quinoline/ naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates", MEDICINAL CHEMISTRY RESEARCH

Buthina Abdallah Saleh Al-Oudat, Bushra Suleiman Abdulqader Abualfool, Suaad Abdallah Saleh Audat, Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Aref Louai Aref Zayed

30/07/2024
"Unraveling Potential Glyoxalase-I Inhibitors Utilizing Structure-Based Drug Design Techniques", Advances and Applications in Bioinformatics and Chemistry

Mohammad Hasan Ismail Fetian, Qosay Ali Elayyan Al-Balas

05/02/2024
"Computational fragment-based drug design of potential Glo-I inhibitors", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Roaa Samer Ahmad Osama Bibars, Qosay Ali Elayyan Al-Balas

22/01/2024
"Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT?P) for Optimal Intelligence and Other Non?Disease?Related Socially Desirable Traits", Journal of Bioethical Inquiry

Qosay Ali Elayyan Al-Balas

04/12/2023
"The practice of defensive medicine among Jordanian physicians: A cross sectional study", PLOS ONE

Qosay Ali Elayyan Al-Balas, Shoroq Mahmoud Mohammad Altawalbeh

09/11/2023
"Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study", Molecules

Qosay Ali Elayyan Al-Balas

26/12/2022
"Computational medicinal chemistry role in clinical pharmacy education: Ingavirin for coronavirus disease 2019 (COVID-19) discovery model", Pharmacy Practice

Qosay Ali Elayyan Al-Balas

08/11/2022
"In Silico and In Vitro Investigation of Anti Helicobacter Activity of Selected Phytochemicals", Journal of Pharmacy and Bioallied Sciences

Qosay Ali Elayyan Al-Balas

19/07/2022
"Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors", Drug Design, Development and Therapy

Suaad Abdallah Saleh Audat, Qosay Ali Elayyan Al-Balas, Buthina Abdallah Saleh Al-Oudat, Mo'Ad Jamil Saeed Athamneh

10/03/2022
"Lead Optimization and Biological Evaluation of Diazenylbenzenesulfonamides Inhibitors Against Glyoxalase-I Enzyme as Potential Anticancer Agents", Bioorganic Chemistry

Buthina Abdallah Saleh Al-Oudat, Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Suaad Abdallah Saleh Audat, Mohammad Ali Yousef Alqudah

02/02/2022
"An Ethical Roadmap for Prioritizing Medical Resources Within Muslim Societies During the COVID?19 Pandemic", Journal of Religion and Health

Qosay Ali Elayyan Al-Balas

08/07/2021
"The ethics of practicing defensive medicine in Jordan: a diagnostic study", BMC Med Ethics

Qosay Ali Elayyan Al-Balas, Hassan Ali Elayan Al Balas

28/06/2021
"Identification of the first "two digit nano-molar" inhibitors of the human glyoxalase-I enzyme as potential anticancer agents.", Medicinal Chemistry

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Esra'A Omar Mohammad Al-Zoubi

26/05/2021
"Molecular docking and dynamic studies of a potential therapeutic target inhibiting glyoxalase system: Metabolic action of the 3, 3 ?- [3- (5-chloro-2-hydroxyphenyl) -3-oxopropane-1, 1-diyl] - Bis-4-hydroxycoumarin leads overexpression of the intracellular level of methylglyoxal and induction of a pro-apoptotic phenomenon in a hepatocellular carcinoma model", Chemico-Biological Interactions

Qosay Ali Elayyan Al-Balas, Ghazi Ahmad Aljabal

05/05/2021
"Carnosine to Combat Novel Coronavirus (nCoV): Molecular Docking and Modeling to Cocrystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein", Molecules

Qosay Ali Elayyan Al-Balas

27/11/2020
"Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents", Bioorganic & Medicinal Chemistry

Buthina Abdallah Saleh Al-Oudat, Hana' Mohammad Khair Ahmad Jaradat, Qosay Ali Elayyan Al-Balas, Nizar Ali Ahmad Al-Shar'I

22/06/2020
"Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking", Molecules

Suaad Abdallah Saleh Audat, Nizar Ali Ahmad Al-Shar'I, Buthina Abdallah Saleh Al-Oudat, Aref Louai Aref Zayed, Qosay Ali Elayyan Al-Balas

19/06/2020
"Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold", Acta Pharmaceutica

Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Tamam Mohammad Murshed El-Elimat, Ammar Muntaser Habes Almaaytah

21/03/2020
"The Ethics of Gene Editing from an Islamic Perspective: A Focus on the Recent Gene Editing of the Chinese Twins", Science and Engineering Ethics

Qosay Ali Elayyan Al-Balas

25/02/2020
"Combined High Throughput Screening with QSAR Analysis Unravelling Potential Glyoxalase-I Inhibitors ", Current Computer-Aided Drug Design

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan

15/01/2020
"Discovery of a nanomolar glyoxalase-I inhibitor using integrated ligand-based pharmacophore modeling and molecular docking", Medicinal Chemistry Research

Nizar Ali Ahmad Al-Shar'I, Enas Khaled Saleh Al-Rousan, Lara Ishaq Issa Alfakhori, Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan

27/11/2019
"Development of analytical methods GC-MS vs LC-UV for the serum monitoring of an inflammatory glycotoxin (methylglyoxal): A new biomarker of bovine hepatobiliary distomatosis", Biochimie

Qosay Ali Elayyan Al-Balas, Ghazi Ahmad Aljabal

03/11/2019
"Discovery of a Nanomolar Inhibitor of the Human Glyoxalase-I Enzyme Using Structure-Based Poly-pharmacophore Modelling and Molecular Docking", Journal of Computer-Aided Molecular Design

Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Rand Ahed Mahmoud Al-Waqfi, Mohammad Abdelhafeez Abdelqader Hassan, Amer Ezzo Al Khalifa, Nehad M. M. Ayoub

21/09/2019
"Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors", Molecules

Qosay Ali Elayyan Al-Balas, Mousa Lafi Hasan Al-Smadi, Mohammad Abdelhafeez Abdelqader Hassan, Ghazi Ahmad Aljabal, Ammar Muntaser Habes Almaaytah, Karem Hasan Mohammad Al-Zoubi

01/09/2019
"Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment.", Molecular biology reports

Karem Hasan Mohammad Al-Zoubi, Arwa Samir I. Hilo, Qosay Ali Elayyan Al-Balas, Khalid Issa Salem El-Salem, Tamam Mohammad Murshed El-Elimat

12/06/2019
"Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents", Computational Biology and Chemistry

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Ghazi Ahmad Aljabal, Ammar Muntaser Habes Almaaytah

22/03/2019
"Synthesis, molecular docking and evaluation of hypolipidemic activities of novel benzophenonecarboxamide derivatives", Indian Journal of Chemistry -Section B (IJC-B)

Qosay Ali Elayyan Al-Balas

13/03/2019
"Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends", Current Pharmaceutical Design

Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas

26/02/2019
"Traditional Islamic approach can enrich CRISPR twins debate", Nature

Qosay Ali Elayyan Al-Balas

19/02/2019
"Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators", Drug Design, Development and Therapy

Buthina Abdallah Saleh Al-Oudat, Mohammad Ali Yousef Alqudah, Suaad Abdallah Saleh Audat, Qosay Ali Elayyan Al-Balas, Tamam Mohammad Murshed El-Elimat, Mohammad Abdelhafeez Abdelqader Hassan

15/12/2018
"Physicochemical characterization and determination of chloramphenicol residues and heavy metals in Algerian honeys", Environmental Science and Pollution Research

Qosay Ali Elayyan Al-Balas

13/09/2018
"In vivo antimicrobial activity of the hybrid peptide H4: a follow-up study", Infection and Drug Resistance

Ammar Muntaser Habes Almaaytah, Qosay Ali Elayyan Al-Balas, Karem Hasan Mohammad Al-Zoubi

05/07/2018
"Recent Advances in Glyoxalase-I Inhibition", Mini-Reviews in Medicinal Chemistry

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Nizar Ali Ahmad Al-Shar'I, Ghazi Ahmad Aljabal, Ammar Muntaser Habes Almaaytah

01/07/2018
"A3, a Scorpion Venom Derived Peptide Analogue with Potent Antimicrobial and Potential Antibiofilm Activity against Clinical Isolates of Multi-Drug Resistant Gram Positive Bacteria", Molecules

Ammar Muntaser Habes Almaaytah, Ahmed M. A. Farajallah, Ahmad Khaled Shafeeq Abo_Alhijaa, Qosay Ali Elayyan Al-Balas

22/06/2018
"Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides", Infection and Drug Resistance

Ammar Muntaser Habes Almaaytah, Mohammed Talal Nouh Qaoud, Ahmad Khaled Shafeeq Abo_Alhijaa, Qosay Ali Elayyan Al-Balas, Karem Hasan Mohammad Al-Zoubi

06/04/2018
"Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase-I inhibitors", Drug Development Research

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Nizar Ali Ahmad Al-Shar'I, Tamam Mohammad Murshed El-Elimat, Ammar Muntaser Habes Almaaytah

16/12/2017
"Development of Novel Ultrashort Antimicrobial Peptide Nanoparticles with Potent Antimicrobial and Antibiofilm Activities against Multidrug Resistant Bacteria", Drug Design, Development and Therapy

Ammar Muntaser Habes Almaaytah, Gubran Khalil Ebrahim Mohammed, Ahmad Khaled Shafeeq Abo_Alhijaa, Qosay Ali Elayyan Al-Balas

06/10/2017
"Development of novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial and antibiofilm activities against multidrug-resistant bacteria", Drug Design, Development and Therapy

Ammar Muntaser Habes Almaaytah, Gubran Khalil Ebrahim Mohammed, Ahmad Khaled Shafeeq Abo_Alhijaa, Qosay Ali Elayyan Al-Balas

05/10/2017
"Novel Thiazole Carboxylic Acid Derivatives Possessing a ?Zinc Binding Feature? as Potential Human Glyoxalase-I Inhibitors", Letters in Drug Design & Discovery

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Ghazi Ahmad Aljabal, Nizar Ali Ahmad Al-Shar'I, Ammar Muntaser Habes Almaaytah, Tamam Mohammad Murshed El-Elimat

22/02/2017
"Biological activities and phenolic contents of Argania spinosa L (Sapotaceae) leaf extract", Tropical Journal of Pharmaceutical Research

Ahmad Khaled Shafeeq Abo_Alhijaa, Ammar Muntaser Habes Almaaytah, Qosay Ali Elayyan Al-Balas

16/11/2016
"Scorpion venom peptides with no disulfide bridges: A review", Peptides

Ammar Muntaser Habes Almaaytah, Qosay Ali Elayyan Al-Balas

15/10/2013

Dean , Faculty Of Pharmacy, Oct 2024 - Present
Head of the Center, Pharmaceutical Research, Sep 2014 - Sep 2016
Deputy Head of Department, Department of Medicinal Chemistry and Pharmacognosy, Sep 2011 - Sep 2013
Assistant Dean, Faculty Of Pharmacy, Sep 2009 - Aug 2010
Faculty Member, Department of Medicinal Chemistry and Pharmacognosy, Aug 2008 - Present
Full-time Lecturer, Department of Medicinal Chemistry and Pharmacognosy, Jun 2008 - Aug 2008

Senior Herbal Analyst, Arab Pharmaceutical Manufacturing (APM) , Jordan, Jul 2003- Apr 2004
Pharmacist in Charge, Community Pharmacy , Jordan, Jun 2000- Jun 2003

ADVANCED DRUG DESIGN
ADVANCED MEDICINAL CHEMISTRY
ADVANCED ORGANIC SYNTHESIS
CHEMISTRY OF HETEROCYCLIC
CHROMATOGRAPHY
DRUG DESIGN
DRUG DESIGN AND SYNTHESIS
DRUG DESIGN AND SYRTHESIS
FOUNDATIONS OF BIOETHICS
ISLAMIC THEOLOGICAL AND RELIGIOUS ASPECTS OF BIOETHICS
MEDICINAL CHEMISTRY (1)
MEDICINAL CHEMISTRY (2)
MEDICINAL CHEMISTRY 2
MEDICINAL CHEMISTRY LAB
MEDICINAL CHEMISTRY( 3)
MEDICINAL CHEMISTRY( 4)
MEDICINAL CHEMISTRY(2)
MEDICINAL CHEMISTRY(3)
MOLECULAR MODELING AND COMPUTER-AIDED DRUG DESIGN
Medicinal Chemistry 1 (for Pharm D students)
Medicinal Chemistry 2 (for Pharm D students)
PHARMACEUTICAL PRACTICAL TRAINING
PHARMACEUTICAL ORGANIC CHEMISTRY
PHARMACOGNOSY AND PHYTOCHEMISTRY LAB ORATORY
RESEARCH METHODOLOGY
SELECTED TOPICS ( 1)
SELECTED TOPICS ( 2)
SELECTED TOPICS IN MEDICINAL CHEMISTRY
SEMINAR
SPECIAL TOPICS (C)
STEREOCHEMISTRY