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othman abdullah al-shboul
Department of physiology and Biochemistry - Faculty Member

  • Ph.D. of Physiology from Virginia Commonwealth University, 2011
  • Bsc. of Dentistry from Jordan University of Science and Technology, 2004

    Publications
  • Othman Al-Shboul; Ayman Mustafa; Farah Al-hashimi, "Non-genomic effects of progesterone on Rho kinase II in rat gastric smooth muscle cells.," Journal of Smooth Muscle Research, vol. 49, no. , pp. 55-62, 2013
  • Othman Al-Shboul, "The importance of interstitial cells of cajal in the gastrointestinal tract.," Saudi Journal Gastroenterology, vol. 19, no. , pp. 3-15, 2013
  • Othman Al-Shboul, S. Mahavadi, W. Sirwai, JR. Grider, KS. Murthy, "Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle.," American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 305, no. , pp. 314-324, 2013
  • Ayman G. Mustafa, Othaman A. Al-Shboul, , "Pathophysiology of traumatic brain injury," Neurosciences , vol. 18, no. 3, pp. 222-234, 2013
  • Rashad Ahmed, Sunila Mahavadi, Othman Al-Shboul, Sayak Bhattacharya, John R. Grider, and Karnam S. Murthy, "Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle," Regulatory peptides, vol. 184, no. , pp. 96-103, 2013
  • Reem Alkahtani, Sunila Mahavadi, Othman Al-Shboul, Shakir Alsharari, John R. Grider, and Karnam S. Murthy, "Changes in the expression of smooth muscle contractile proteins in TNBS- and DSS-induced colitis in mice," Inflammation, vol. 36, no. 6, pp. 1304-1315, 2013
  • Othman Abdullah Al-Shboul • Ayman Mustafa • Mukhallad Mohammad • Mustafa Al-Shehabat • Asmaa Yousef • Farah Al-hashimi, "Effect of Oxidative Stress on the Expression of Thin Filament- Associated Proteins in Gastric Smooth Muscle Cells," Cell biochemistry and biophysics, vol. 70, no. 1, pp. 225-231, 2014
  • Mukhallad A. M. Mohammad & Muhanad S. Abdelwahab & Mohamad M. J. Mohamad & Othman El shboul & Waleed R. Ezzat, "Cardiac myosin heavy chains in mice treated with NG-nitro-L -arginine methyl ester and thyroxine," Comparative Clinical Pathology, vol. 23, no. , pp. 1639-1644, 2013
  • Sayak Bhattacharya, Sunila Mahavadi, Othman Al-Shboul, Senthilkumar Rajagopal, John R. Grider, and Karnam S. Murthy, "Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1," American Journal of Physiology-Cell Physiology, vol. 305, no. 3, pp. 334-347, 2013
  • Othman Al-Shboul and Ayman Mustafa, "Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach," Canadian journal of physiology and pharmacology, vol. 93, no. 6, pp. 405-411, 2015
  • Wimolpak Sriwai, Sunila Mahavadi, Othman Al-Shboul, John R. Grider, Karnam S. Murthy, "Distinctive G Protein-Dependent Signaling by Protease- Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA," PloS one, vol. 8, no. 6, pp. 66743-66743,
  • Sunila Mahavadi • Ancydimpy Nalli • Othman Al-Shboul • Karnam S. Murthy, "Inhibition of MLC20 Phosphorylation Downstream of Ca2+ and RhoA: A Novel Mechanism Involving Phosphorylation of Myosin Phosphatase Interacting Protein (M-RIP) by PKG and Stimulation of MLC Phosphatase," Cell biochemistry and biophysics, vol. 68, no. 1, pp. 1-8, 2013
  • Ancy D. Nalli, Divya P. Kumar, Sunila Mahavadi, Othman Al-Shboul, Reem Alkahtani, John F. Kuemmerle, John R. Grider, and Karnam S. Murthy, "Hypercontractility of Intestinal Longitudinal Smooth Muscle Induced by Cytokines Is Mediated by the Nuclear FactorkB/ AMP-Activated Kinase/Myosin Light Chain Kinase Pathway," Journal of Pharmacology and Experimental Therapeutics, vol. 350, no. 1, pp. 89-98, 2014
  • Othman Al-Shboul, Ancy D. Nalli, Divya P. Kumar, Ruizhe Zhou, Sunila Mahavadi, John F. Kuemmerle, John R. Grider, and Karnam S. Murthy, "Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation," American Journal of Physiology-Cell Physiology, vol. 306, no. 12, pp. 1129-1141,
  • Sunila Mahavadi, Sayak Bhattacharya, Jennnifer Kim, Sally Fayed, Othman Al-Shboul, John R. Grider, and Karnam S. Murthy, "Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC2, in gastrointestinal smooth muscle," Peptides, vol. 43, no. , pp. 137-145,
  • Ancy D. Nalli • Divya P. Kumar • Othman Al-Shboul • Sunila Mahavadi • John F. Kuemmerle • John R. Grider • Karnam S. Murthy, "Regulation of Gbci-Dependent PLC-b3 Activity in Smooth Muscle: Inhibitory Phosphorylation of PLC-b3 by PKA and PKG and Stimulatory Phosphorylation of Gai-GTPase-Activating Protein RGS2 by PKG," Cell biochemistry and biophysics, vol. 70, no. 2, pp. 867-880, 2014
  • Othman Al-Shboul, "The role of the RhoA/ROCK pathway in gender-dependent differences in gastric smooth muscle contraction," The Journal of Physiological Sciences, vol. , no. , pp. 1-8, 2015
  • Mohammad Al-Qudah*, Doaa Abu Shammala, Ahmed Al-Dwairi, "DIFFERENTIAL EXPRESSION OF NEUROTROPHINS IN (DSS)-INDUCED COLITIS IN SMOOTH MUSCLE OF RAT COLON," Jurnal Teknologi, vol. 78, no. 5?5, pp. 27-31, 2016
  • Mohammad Al-Qudah, Doaa Abu Shammala, Ahmed Al-Dwairi, Othman Al-Shboul, Ayman G Mustafa, "Dextran sodium sulphate (DSS)-induced colitis alters the expression of neurotrophins in smooth muscle cells of rat colon," Physiological Research, vol. 66, no. 6, pp. 1009-1020, 2017
  • Ahmed Al-Dwairi,1 Tamara E Alqudah,1 Othman Al-Shboul,1 Mohammad Alqudah,1 , "Glucagon-like peptide-1 exerts anti-inflammatory effects on mouse colon smooth muscle cells through the cyclic adenosine monophosphate/nuclear factor-?B pathway in vitro," Journal of Inflammation Research, vol. 11, no. , pp. 95-109, 2018
  • Al-dwairi, Ahmed and Al-shboul, Othman and Alqudah, Mohammad and Mustafa, Ayman G and Alfaqih, Mahmoud A, "EFFECT OF INSULIN ON LPS-INDUCED INFLAMMATORY MARKERS IN MOUSE COLON SMOOTH MUSCLE CELLS IN VITRO," Asian J Pharm Clin Res, vol. 11, no. 4, pp. 105-109, 2018
  • Mustafa, Ayman G and Al-Shboul, Othman and Alfaqih, Mahmoud A and Al-Qudah, Mohammad A and Al-Dwairi, Ahmed N, "Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins," Archives of physiology and biochemistry, vol. 124, no. 5, pp. 418-423, 2018
  • Al-Shboul, Othman A and Al-Dwairi, Ahmed N and Alqudah, Mohammad A and Mustafa, Ayman G, "Gender differences in the regulation of MLC20 phosphorylation and smooth muscle contraction in rat stomach Corrigendum in/10.3892/br. 2019.1252," Biomedical reports, vol. 8, no. 3, pp. 283-288, 2018
  • Al-Shboul, O, "Contraction and relaxation signaling in gastrointestinal smooth muscle," EC Gastroenterology and Digestive System, vol. 5, no. 5, pp. 315-321, 2018
  • Alfaqih, Mahmoud A and Khader, Yousef S and Al-Dwairi, Ahmed N and Alzoubi, Abdallah and Al-Shboul, Othman and Hatim, Amanie, "Lower levels of serum adiponectin and the T allele of rs1501299 of the ADIPOQ gene are protective against polycystic ovarian syndrome in Jordan," Korean journal of family medicine, vol. 39, no. 2, pp. 108-113, 2018
  • Al-Dwairi, Ahmed and Alqudah, Mohammad and Al-Shboul, Othman and Alfaqih, Mahmoud and Alomari, Dana, "Metformin exerts anti-inflammatory effects on mouse colon smooth muscle cells in vitro," Experimental and therapeutic medicine, vol. 16, no. 2, pp. 985-992, 2018
  • Al-Shboul, Othman A and Nazzal, Mona S and Mustafa, Ayman G and Al-Dwairi, Ahmed N and Alqudah, Mohammad A and Abu Omar, Amal and Alfaqih, Mahmoud A and Alsalem, Mohammad I, "Estrogen relaxes gastric muscle cells via a nitric oxide-and cyclic guanosine monophosphate-dependent mechanism: A sex-associated differential effect," Experimental and therapeutic medicine, vol. 16, no. 3, pp. 1685-1692, 2018
  • Mustafa, Ayman G and Alfaqih, Mahmoud A and Al-Shboul, Othman, "The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions," Experimental and therapeutic medicine, vol. 16, no. , pp. 2132-2137, 2018
  • Alfaqih, Mahmoud A and Abu-Khdair, Zaina and Saadeh, Rami and Saadeh, Nesreen and Al-Dwairi, Ahmed and Al-Shboul, Othman, "Serum branched chain amino acids are associated with type 2 diabetes mellitus in Jordan," Korean journal of family medicine, vol. 39, no. , pp. 0-0, 2018, Korean Academy of Family Medicine
  • Mustafa, Ayman G and Alfaqih, Mahmoud A and Al-Shboul, Othman and Al-Dwairi, Ahmed, "Scavenging of lipid peroxyl radicals protects plasma lipids and proteins from peroxynitrite," Biomedical reports, vol. 9, no. 5, pp. 421-426, 2018
  • Al-Shboul, Othman A and Mustafa, Ayman G and Omar, Amal Abu and Al-Dwairi, Ahmed N and Alqudah, Mohammad A and Nazzal, Mona S and Alfaqih, Mahmoud A and Al-Hader, Rami A, "Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells Corrigendum in/10.3892/br. 2019.1251," Biomedical reports, vol. 9, no. , pp. 511-516, 2018
  • Alfaqih, Mahmoud A and Al-Mughales, Faheem and Al-Shboul, Othman and Al Qudah, Mohammad and Khader, Yousef S and Al-Jarrah, Muhammad, "Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan," Biomolecules, vol. 8, no. 4, pp. 108-113, 2018
  • Aldossary, Sara A and Alsalem, Mohammad and Kalbouneh, Heba and Haddad, Mansour and Azab, Belal and Al-shboul, Othman and Mustafa, Ayman G and Obiedat, Sarah and El-Salem, Khalid, "The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-$\alpha$ in mediating the antinociceptive effects of palmitoylethanolamine in rats," NeuroReport, vol. 30, no. , pp. 32-37, 2019, LWW
  • Alfaqih, Mahmoud A and Khader, Yousef S and Al-Dwairi, Ahmed N and Alzoubi, Abdallah and Al-Shboul, Othman and Hatim, Amanie, "Correction: Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of the ADIPOQ Gene Are Protective against Polycystic Ovarian Syndrome in Jordan," Korean journal of family medicine, vol. 39, no. , pp. 207-207, 2018, Korean Academy of Family Medicine
  • Al-Shboul, Othman A and Al-Rshoud, Hanan J and Al-Dwairi, Ahmed N and Alqudah, Mohammad A and Alfaqih, Mahmoud A and Mustafa, Ayman G and Jaafar, Mohammad, "Changes in gastric smooth muscle cell contraction during pregnancy: effect of estrogen," Journal of pregnancy, vol. 2019, no. , pp. 1-8, 2019
  • Al-Shboul, Othman and Alfaqih, Mahmoud and Mustafa, Ayman and Al-Dwairi, Ahmed and Alqudah, Mohammad and Haifawi, Saja and Alebbini, Mohanad and Al-Zaareer, Mohammad and Alahmar, Khobaib, "Developmental changes in contraction of gastric smooth muscle cells in rats correlate with their differences in RhoA/ROCK pathway," Journal of Biomedical Research, vol. 33, no. , pp. 0-0, 2019, Education Department of Jiangsu Province
  • Al-Dwairi, Ahmed and Alqudah, Tamara E and Al-Shboul, Othman and Alqudah, Mohammad and Mustafa, Ayman G and Alfaqih, Mahmoud A, "Glucagon-Like Peptide-1 Exerts Anti-Inflammatory Effects On Mouse Colon Smooth Muscle Cells Through The Cyclic Adenosine Monophosphate/Nuclear Factor-$\kappa$B Pathway In Vitro [Corrigendum]," Journal of Inflammation Research, vol. 12, no. 11, pp. 95-109, 2019
  • Alqudah, Mohammad and Balousha, Samar AM and Al-Shboul, Othman and Al-Dwairi, Ahmed and Alfaqih, Mahmoud A and Alzoubi, Karem H, "Insomnia among medical and paramedical students in Jordan: impact on academic performance," BioMed research international, vol. 2019, no. , pp. 0-0, 2019
  • Al-Shboul, Othman A and Al-Dwairi, Ahmed N and Alqudah, Mohammad A and Mustafa, Ayman G, "[Corrigendum] Gender differences in the regulation of MLC20 phosphorylation and smooth muscle contraction in rat stomach," Biomedical Reports, vol. 11, no. 3, pp. 275-275, 2019
  • Mustafa, Ayman G and Alfaqih, Mahmoud A and Al-Shboul, Othman and Al-Dwairi, Ahmed, "[Corrigendum] Scavenging of lipid peroxyl radicals protects plasma lipids and proteins from peroxynitrite," Biomedical Reports, vol. 12, no. 5, pp. 35-35, 2020
  • Al Qudah, Mohammad and Alfaqih, Mahmoud and Al-Shboul, Othman and Saadeh, Rami and Al-Dwairi, Ahmed, "Effect of cytokine treatment on the expression and secretion of brain derived neurotrophic factor in the smooth muscle of the rat colon," Biomedical Reports, vol. 13, no. 1, pp. 55-60, 2020
  • Aldossary, Sara A and Alsalem, Mohammad and Kalbouneh, Heba and Haddad, Mansour and Azab, Belal and Al-Shboul, Othman and Mustafa, Ayman G and Obiedat, Sarah and El-Salem, Khalid, "The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-alpha in mediating the antinociceptive effects of palmitoylethanolamine in rats (vol 30, pg 32, 2019)," NEUROREPORT, vol. 31, no. 1, pp. 85-85, 2019
  • Alfaqih, Mahmoud A and Mustafa, Ayman G and Al-shboul, Othman, "The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions," , 2018, pp. 0-0, BioScientifica
  • "Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan", Biomolecules
  • "Changes in Gastric Smooth Muscle Cell Contraction during Pregnancy: Effect of Estrogen", Journal of Pregnancy
  • "Correlation between vitamin D and serum brain derived neurotropic factor levels in type 2 diabetes mellitus patients", biomedical reports
  • "DIFFERENTIAL EXPRESSION OF NEUROTROPHINS IN (DSS)-INDUCED COLITIS IN SMOOTH MUSCLE OF RAT COLON", Jurnal Teknologi (Sciences and Engineering)
  • "Developmental changes in contraction of gastric smooth muscle cells in rats correlate with their differences in RhoA/ROCK pathway", Journal of Biomedical Research
  • "Dextran Sodium Sulphate (DSS)-Induced Colitis Alters the Expression of Neurotrophins in Smooth Muscle Cells of Rat Colon", physiological research
  • "Effect of Oxidative Stress on the Expression of Thin Filament- Associated Proteins in Gastric Smooth Muscle Cells", Cell Biochemistry and Biophysics
  • "Effect of cytokine treatment on the expression and secretion of brain derived neurotrophic factor in the smooth muscle of the rat colon", Biomedical reports
  • "Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells", Biomedical Reports
  • "Estrogen relaxes gastric muscle cells via a nitric oxide? and cyclic guanosine monophosphate?dependent mechanism: A sex?associated differential effect", Experimental and Therapeutic Medicine
  • "Gender differences in the regulation of MLC20 phosphorylation and smooth muscle contraction in rat stomach", Biomedical Reports
  • "Glucagon-like peptide-1 exerts anti-inflammatory effects on mouse colon smooth muscle cells through the cyclic adenosine monophosphate/nuclear factor-?B pathway in vitro", Journal of Inflammation Research
  • "Implications of enigmatic transglutaminase 2 (TG2) in cardiac diseases and therapeutic developments", Biochemical Pharmacology
  • "Insomnia among Medical and Paramedical Students in Jordan: Impact on Academic Performance", BioMed Research International
  • "Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of the ADIPOQ Gene Are Protective against Polycystic Ovarian Syndrome in Jordan", Korean Journal of Family Medicine
  • "Metformin exerts anti-inflammatory effects on mouse colon smooth muscle cells in vitro", Experimental and Therapeutic Medicine
  • "Morphometric Study of the Hard Palate and Its Relevance to Dental and Forensic Sciences", international journal of dentistry
  • "Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins", Archives of Physiology and Biochemistry The Journal of Metabolic Diseases
  • "Progesterone Inhibitory Role on Gastrointestinal Motility", physiological research
  • "Scavenging of lipid peroxyl radicals protects plasma lipids and proteins from peroxynitrite", biomedical reports
  • "Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan", Korean Journal of Family Medicine
  • "The 4?hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions", experimental and therapeutic medicine
  • "The importance of interstitial cells of cajal in the gastrointestinal tract", Saudi Journal of Gastroenterology
  • "The role of the RhoA/ROCK pathway in gender-dependent differences in gastric smooth muscle contraction", The Physiological Sciences
  • "The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-? in mediating the antinociceptive effects of palmitoylethanolamine in rats", NEUROREPORT
  • "pathophysiology of traumatic brain injury", neurosciences (riyadh)
  • Deputy Head of Department, Department of physiology and Biochemistry, Sep 2014 - Sep 2016
  • Faculty Member, Department of physiology and Biochemistry, Jul 2011 - Present
  • ADVANCED GASTROINTESTINAL SYSTEM
  • ADVANCED HUMAN PHYSIOLOGY
  • ENDOCRINOLOGY AND REPRODUCTION
  • FIRST AID
  • GASTRO-INTESTINAL SYSTEM
  • HUMAN PHYSIOLOGY
  • HUMAN PHYSIOLOGY (LAB)
  • HUMAN PHYSIOLOGY FOR STUDENTS OF DENTISTRY
  • HUMAN PHYSIOLOGY LAB FOR STUDENTS OF DENTISTRY
  • NEUROSCIENCE (1)
  • PATHOPHYSIOLOGY
  • PHYSIOANATOMY LAB
  • SEMINAR
  • TEACHING SKILLS
    Technical Paper Reviews
  • Saudi Journal of Gastroenterology, Journal
  • Heighpubs Journal of Biology and Medicine, Journal
  • Heighpubs Clinical Gastroenterology, Journal
  • World Journal of Gastrointestinal Pathophysiology, Journal
    Conference Duties
  • Digestive Disease Week (DDW), U.S.A, Key Notes Speaker
    Editorial Boards
  • Gastro Open Access Journal, 2014 -2015
  • EC Neurology, 2017 -2017
  • International Journal of Anatomy & Applied Physiology (IJAAP), 2016 -2017
  • World Journal of Gastrointestinal Pathophysiology, 2016 -2017
    Professional Memberships
  • Honor Society of Phi Kappa Phi, 2009
  • Golden Key International Honor Society, 2008
  • Member of American Physiology Society (APS), 2010