×
nizar ali al-shar'i
• Department of Medicinal Chemistry and Pharmacognosy - Faculty Member

  • Ph.D. of Pharmacy from University of Strathclyde, 2013
  • Msc. of Pharmacy from Jordan University of Science and Technology, 2007
  • Bsc. of Pharmacy from Jordan University of Science and Technology, 2001

    Publications
  • Nizar A. Al-Shar’i,  Mohammad Hassan,  Qosay Al-Balas,  Ammar Almaaytah., "Identification of Possible Glyoxalase II Inhibitors as Anticancer Agents by a Customized 3D Structure-Based Pharmacophore Model," Jordan Journal of Pharmaceutical Sciences, vol. 8, no. 2, pp. 83-103, 2015
  • Ammar Almaaytah,  Shadi Tarazi,  Mohammad Al-Fandi,  Ahmad Abuilhaija,  Nizar Al-shar’i,  Qosay Al-Balas,  Aymen Abu-Awad. , "The Design and Functional Characterization of the Antimicrobial and Antibiofilm Activities of BMAP27-Melittin, a Rationally Designed Hybrid Peptide," International Journal of Peptide Research and Therapeutics, vol. 21, no. , pp. 165-177, 2014
  • Ammar Almaaytah,  Shadi Tarazi,  Ahmad Abu-Alhaijaa,  Yara Altall,  Nizar Al-Shar’i,  Khaldon Bodoor,  Qosay Al-Balas. , "Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1," Pharmaceuticals, vol. 7, no. , pp. 502-516, 2014
  • Amjad M. Qandil Mohammad A. Hassan Nizar A. Al-Shar'i, "Synthesis and Anticandidal Activity of Azole-Containing Sulfonamides," Archiv der Pharmazie, vol. 341, no. , pp. 99-112, 2007
  • Soraya M. Alnabulsi,  Nizar A. Al-Shar'i., "Hit Identification of an SMYD3 Enzyme Inhibitor Using Structure-Based Pharmacophore Modelling," Future Medicinal Chemistry, vol. 11, no. 10, pp. 1107-1117, 2019
  • Nizar A. Al-Shar’i,  Qosay A. Al-Balas. , "Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends," Current Pharmaceutical Design, vol. 25, no. 7, pp. 783-816, 2019
  • Qosay A. Al-Balas, Mohammad A. Hassan, Nizar A. Al-Shar'i, Ghazi A. Al Jabal and Ammar M. Almaaytah., "Recent Advances in Glyoxalase-I Inhibition," Mini-Reviews in Medicinal Chemistry, vol. 19, no. 4, pp. 281-291, 2019
  • Qosay Ali Al-Balas, Nizar A. Al-Shar’i, Mohammad A. Hassan, Katreen banisalman., "Design, Synthesis and Biological Evaluation of potential Novel Zinc Binders Targeting Human Glyoxalase-I; A Validated Target for Cancer Treatment," Jordan Journal of Pharmaceutical Sciences, vol. 11, no. 1, pp. 25-37, 2018
  • Nizar A. Al-Shar’i, Rana Obaidat., "Experimental and Computational Comparative Study of the Supercritical Fluid Technology (SFT) and Kneading Method in Preparing ?-Cyclodextrin Complexes with Two Essential Oils (Linalool and Carvacrol)," AAPS PharmSciTech, vol. 19, no. 3, pp. 1037-1047, 2018
  • Qosay A. Al-Balas, Mohammad A. Hassan, Nizar A. Al-Shar’i, Tamam El-Elimat, Ammar M. Almaaytah. , "Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors," Drug Development Research, vol. 79, no. 2, pp. 58-69, 2018
  • "1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis and In Silico Molecular Docking Study", Molecules
  • "Amino-carboxamide benzothiazoles as potential LSD1 hit inhibitors. Part I: Computational fragment-based drug design", Journal of Molecular Graphics and Modelling
  • "Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives", Antibiotics
  • "CHK1 kinase inhibition: identification of allosteric hits using MD simulations, pharmacophore modeling, docking and MM-PBSA calculations", Molecular Diversity
  • "Co-crystallization of Amoxicillin Trihydrate and Potassium Clavulanate Provides a Promising Approach for Preparation of Sustained-Release Microspheres", AAPS PharmSciTech
  • "Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase-I inhibitors", Drug Development Research
  • "Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents", Bioorganic & Medicinal Chemistry
  • "Design, synthesis, and biological evaluation of SMYD3 inhibitors possessing N-thiazole benzenesulfonamide moiety as potential anti-cancer agents", Journal of Saudi Chemical Society
  • "Developmental Landscape of Potential Vaccine Candidates Based on Viral Vector for Prophylaxis of COVID-19", Frontiers in Molecular Biosciences
  • "Discovery of a Nanomolar Inhibitor of the Human Glyoxalase-I Enzyme Using Structure-Based Poly-pharmacophore Modelling and Molecular Docking", Journal of Computer-Aided Molecular Design
  • "Discovery of a nanomolar glyoxalase-I inhibitor using integrated ligand-based pharmacophore modeling and molecular docking", Medicinal Chemistry Research
  • "Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold", Acta Pharmaceutica
  • "Evaluation and Characterization of Curcumin-?-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation", polymers
  • "Evaluation of EDTA Dianhydride Versus Diphenyl Carbonate Nanosponges for Curcumin", AAPS PharmSciTech
  • "Experimental and Computational Comparative Study of the Supercritical Fluid Technology (SFT) and Kneading Method in Preparing ?-Cyclodextrin Complexes with Two Essential Oils (Linalool and Carvacrol)", AAPS PharmSciTech
  • "Hit identification of SMYD3 enzyme inhibitors using structure-based pharmacophore modeling", Future Medicinal Chemsiitry
  • "Identification of CHK1 Kinase Inhibitors Using Structure- Based Pharmacophore Modelling and Molecular Docking", Indian Journal of Pharmaceutical Sciences
  • "Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking", Molecules
  • "In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis", Journal of Enzyme Inhibition and Medicinal Chemistry
  • "Lead Optimization and Biological Evaluation of Diazenylbenzenesulfonamides Inhibitors Against Glyoxalase-I Enzyme as Potential Anticancer Agents", Bioorganic Chemistry
  • "Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends", Current Pharmaceutical Design
  • "Neurological consequences of SARS-CoV-2 infection and concurrence of treatment-induced neuropsychiatric adverse events in COVID-19 patients: Navigating the uncharted", Frontiers in Molecular Biosciences
  • "Novel Thiazole Carboxylic Acid Derivatives Possessing a ?Zinc Binding Feature? as Potential Human Glyoxalase-I Inhibitors", Letters in Drug Design & Discovery
  • "Perspectives on RNA Vaccine Candidates for COVID-19", Frontiers in Molecular Biosciences
  • "Recent Advances in Glyoxalase-I Inhibition", Mini-Reviews in Medicinal Chemistry
  • "Synthesis, biological evaluation, and computational investigation of ethyl 2,4,6-trisubstituted-1,4-dihydropyrimidine-5-carboxylates as potential larvicidal agents against Anopheles arabiensis", Journal of Biomolecular Structure and Dynamics
  • "Synthesis, characterization and larvicidal studies of ethyl 3-benzoyl-7- (piperidin-1-yl)indolizine-1-carboxylate analogues against Anopheles arabiensis and cheminformatics approaches", JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS
  • "Tackling COVID-19: identification of potential main protease inhibitors via structural analysis, virtual screening, molecular docking and MM-PBSA calculations", Journal of Biomolecular Structure and Dynamics
  • "The design of TOPK inhibitors using similarity search, molecular docking, and MD simulations", JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS
  • "The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model", Molecular Diversity
  • "The impact of cycleanine in cancer research: a computational study", Journal of Molecular Modeling
  • "Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host-Di-rected Therapies", Current Topics in Medicinal Chemistry
  • "Weak complexation of 5-fluorouracil with ?-cyclodextrin, carbonate, and dianhydride crosslinked ?-cyclodextrin: in vitro and in silico studies", Research in Pharmaceutical Sciences
  • Vice Dean, Vice dean, Sep 2020 - Sep 2021
  • Vice Dean, Vice dean, Sep 2019 - Sep 2020
  • Deputy Head of Department, Department of Medicinal Chemistry and Pharmacognosy, Sep 2017 - Sep 2018
  • Deputy Head of Department, Department of Medicinal Chemistry and Pharmacognosy, Sep 2014 - Sep 2017
  • Faculty Member, Department of Medicinal Chemistry and Pharmacognosy, Sep 2013 - Present
  • Assistant Dean, Assistant Dean, Sep 2013 - Sep 2014
  • Full-time Lecturer, Department of Medicinal Chemistry and Pharmacognosy, Apr 2013 - Sep 2013
  • Chair of pharmacy department, International academy for health sciences, Saudi Arabia, Mar 2007- Jul 2009
  • ADVANCED DRUG DESIGN
  • COMMUNITY PHARMACY (FOR PHARM.D STUDENTS)
  • MEDICINAL CHEMISTRY (1)
  • MEDICINAL CHEMISTRY (2)
  • MEDICINAL CHEMISTRY( 3)
  • MEDICINAL CHEMISTRY(2)
  • MOLECULAR MODELING AND COMPUTER-AIDED DRUG DESIGN
  • PHARMACEUTICAL PRACTICAL TRAINING
  • PHARMACEUTICAL ANALYTICAL CHEMISTRY & INSTRUMENTAL ANALYSIS LAB
  • RESEARCH METHODOLOGY
  • SELECTED TOPICS ( 1)
  • SELECTED TOPICS ( 2)
  • SEMINAR
  • SPECIAL TOPICS (A)
    Conference Duties
  • Recent advances in pharmaceutical applications: a focus on vascular biology, Jordan, Co-Chair
  • Zarqa University Second Scientific Day, Jordan, Key Notes Speaker
    Professional Memberships
  • Member in the Jordan Pharmaceutical Association, since January, 2002
  • Registered as a professional pharmacist from the Saudi Commission for Health Specialties, 2008