Nizar Ali Al-Shar'i

JUST A-Z

nizar ali al-shar'i

• Department of Medicinal Chemistry and Pharmacognosy - Faculty Member

26198
PH4-L0
Department of Medicinal Chemistry and Pharmacognosy
nashari@just.edu.jo

Website

Research Gate

Google Scholar

Ph.D. of Pharmacy from University of Strathclyde, 2013
Msc. of Pharmacy from Jordan University of Science and Technology, 2007
Bsc. of Pharmacy from Jordan University of Science and Technology, 2001

Publications

Nizar A. Al-Shar’i, Mohammad Hassan, Qosay Al-Balas, Ammar Almaaytah., "Identification of Possible Glyoxalase II Inhibitors as Anticancer Agents by a Customized 3D Structure-Based Pharmacophore Model," Jordan Journal of Pharmaceutical Sciences, vol. 8, no. 2, pp. 83-103, 2015
Ammar Almaaytah, Shadi Tarazi, Mohammad Al-Fandi, Ahmad Abuilhaija, Nizar Al-shar’i, Qosay Al-Balas, Aymen Abu-Awad. , "The Design and Functional Characterization of the Antimicrobial and Antibiofilm Activities of BMAP27-Melittin, a Rationally Designed Hybrid Peptide," International Journal of Peptide Research and Therapeutics, vol. 21, no. , pp. 165-177, 2014
Ammar Almaaytah, Shadi Tarazi, Ahmad Abu-Alhaijaa, Yara Altall, Nizar Al-Shar’i, Khaldon Bodoor, Qosay Al-Balas. , "Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1," Pharmaceuticals, vol. 7, no. , pp. 502-516, 2014
Amjad M. Qandil Mohammad A. Hassan Nizar A. Al-Shar'i, "Synthesis and Anticandidal Activity of Azole-Containing Sulfonamides," Archiv der Pharmazie, vol. 341, no. , pp. 99-112, 2007
Soraya M. Alnabulsi, Nizar A. Al-Shar'i., "Hit Identification of an SMYD3 Enzyme Inhibitor Using Structure-Based Pharmacophore Modelling," Future Medicinal Chemistry, vol. 11, no. 10, pp. 1107-1117, 2019
Nizar A. Al-Shar’i, Qosay A. Al-Balas. , "Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends," Current Pharmaceutical Design, vol. 25, no. 7, pp. 783-816, 2019
Qosay A. Al-Balas, Mohammad A. Hassan, Nizar A. Al-Shar'i, Ghazi A. Al Jabal and Ammar M. Almaaytah., "Recent Advances in Glyoxalase-I Inhibition," Mini-Reviews in Medicinal Chemistry, vol. 19, no. 4, pp. 281-291, 2019
Qosay Ali Al-Balas, Nizar A. Al-Shar’i, Mohammad A. Hassan, Katreen banisalman., "Design, Synthesis and Biological Evaluation of potential Novel Zinc Binders Targeting Human Glyoxalase-I; A Validated Target for Cancer Treatment," Jordan Journal of Pharmaceutical Sciences, vol. 11, no. 1, pp. 25-37, 2018
Nizar A. Al-Shar’i, Rana Obaidat., "Experimental and Computational Comparative Study of the Supercritical Fluid Technology (SFT) and Kneading Method in Preparing ?-Cyclodextrin Complexes with Two Essential Oils (Linalool and Carvacrol)," AAPS PharmSciTech, vol. 19, no. 3, pp. 1037-1047, 2018
Qosay A. Al-Balas, Mohammad A. Hassan, Nizar A. Al-Shar’i, Tamam El-Elimat, Ammar M. Almaaytah. , "Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors," Drug Development Research, vol. 79, no. 2, pp. 58-69, 2018
"Design, synthesis and biological evaluation of potent thiazolidinedione salicylic acid inhibitors against glyoxalase-I as potential anticancer agents", Medicinal Chemistry Research

Banan Omar Abedullah Alomari, Lara Ishaq Issa Alfakhori, Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas

09/08/2024
"Structural optimization and biological evaluation of quinoline/ naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates", MEDICINAL CHEMISTRY RESEARCH

Buthina Abdallah Saleh Al-Oudat, Bushra Suleiman Abdulqader Abualfool, Suaad Abdallah Saleh Audat, Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Aref Louai Aref Zayed

30/07/2024
"Identification of potent indolizine derivatives against Mycobacterial tuberculosis: In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies", International Journal of Biological Macromolecules

Nizar Ali Ahmad Al-Shar'I

24/06/2024
"The design of TOPK inhibitors using similarity search, molecular docking, and MD simulations", JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS

Nizar Ali Ahmad Al-Shar'I

15/02/2024
"Synthesis, characterization and larvicidal studies of ethyl 3-benzoyl-7- (piperidin-1-yl)indolizine-1-carboxylate analogues against Anopheles arabiensis and cheminformatics approaches", JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS

Nizar Ali Ahmad Al-Shar'I

05/02/2024
"Synthesis, biological evaluation, and computational investigation of ethyl 2,4,6-trisubstituted-1,4-dihydropyrimidine-5-carboxylates as potential larvicidal agents against Anopheles arabiensis", Journal of Biomolecular Structure and Dynamics

Nizar Ali Ahmad Al-Shar'I

01/06/2023
"The impact of cycleanine in cancer research: a computational study", Journal of Molecular Modeling

Nizar Ali Ahmad Al-Shar'I

04/10/2022
"Evaluation of EDTA Dianhydride Versus Diphenyl Carbonate Nanosponges for Curcumin", AAPS PharmSciTech

Hadeia Ahmad Kaddam Mashaqbeh, Rana Mohammed Khalid Obeidat, Nizar Ali Ahmad Al-Shar'I

16/08/2022
"Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives", Antibiotics

Nizar Ali Ahmad Al-Shar'I

21/06/2022
"1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis and In Silico Molecular Docking Study", Molecules

Nizar Ali Ahmad Al-Shar'I

19/04/2022
"Design, synthesis, and biological evaluation of SMYD3 inhibitors possessing N-thiazole benzenesulfonamide moiety as potential anti-cancer agents", Journal of Saudi Chemical Society

Suaad Abdallah Saleh Audat, Nizar Ali Ahmad Al-Shar'I, Buthina Abdallah Saleh Al-Oudat, Soraya Ma'Moun Othman Alnabulsi

18/04/2022
"Co-crystallization of Amoxicillin Trihydrate and Potassium Clavulanate Provides a Promising Approach for Preparation of Sustained-Release Microspheres", AAPS PharmSciTech

Rana Mohammed Khalid Obeidat, Batool Abedalnaser Mohammad Alghzawi, Bashar Mohammad Yousef Altaani, Nizar Ali Ahmad Al-Shar'I

05/04/2022
"Weak complexation of 5-fluorouracil with ?-cyclodextrin, carbonate, and dianhydride crosslinked ?-cyclodextrin: in vitro and in silico studies", Research in Pharmaceutical Sciences

Hadeia Ahmad Kaddam Mashaqbeh, Rana Mohammed Khalid Obeidat, Nizar Ali Ahmad Al-Shar'I, Tamam Mohammad Murshed El-Elimat, Soraya Ma'Moun Othman Alnabulsi

15/03/2022
"Lead Optimization and Biological Evaluation of Diazenylbenzenesulfonamides Inhibitors Against Glyoxalase-I Enzyme as Potential Anticancer Agents", Bioorganic Chemistry

Buthina Abdallah Saleh Al-Oudat, Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Suaad Abdallah Saleh Audat, Mohammad Ali Yousef Alqudah

02/02/2022
"The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model", Molecular Diversity

Lara Ishaq Issa Alfakhori, Nizar Ali Ahmad Al-Shar'I

01/12/2021
"Evaluation and Characterization of Curcumin-?-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation", polymers

Hadeia Ahmad Kaddam Mashaqbeh, Rana Mohammed Khalid Obeidat, Nizar Ali Ahmad Al-Shar'I

10/11/2021
"In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis", Journal of Enzyme Inhibition and Medicinal Chemistry

Nizar Ali Ahmad Al-Shar'I

03/03/2021
"CHK1 kinase inhibition: identification of allosteric hits using MD simulations, pharmacophore modeling, docking and MM-PBSA calculations", Molecular Diversity

Nizar Ali Ahmad Al-Shar'I, Sondos Sami Ahmad Khairy Musleh

15/02/2021
"Developmental Landscape of Potential Vaccine Candidates Based on Viral Vector for Prophylaxis of COVID-19", Frontiers in Molecular Biosciences

Nizar Ali Ahmad Al-Shar'I

05/02/2021
"Perspectives on RNA Vaccine Candidates for COVID-19", Frontiers in Molecular Biosciences

Nizar Ali Ahmad Al-Shar'I

13/01/2021
"Neurological consequences of SARS-CoV-2 infection and concurrence of treatment-induced neuropsychiatric adverse events in COVID-19 patients: Navigating the uncharted", Frontiers in Molecular Biosciences

Nizar Ali Ahmad Al-Shar'I

12/01/2021
"Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host-Di-rected Therapies", Current Topics in Medicinal Chemistry

Nizar Ali Ahmad Al-Shar'I

19/11/2020
"Tackling COVID-19: identification of potential main protease inhibitors via structural analysis, virtual screening, molecular docking and MM-PBSA calculations", Journal of Biomolecular Structure and Dynamics

Nizar Ali Ahmad Al-Shar'I

17/07/2020
"Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents", Bioorganic & Medicinal Chemistry

Buthina Abdallah Saleh Al-Oudat, Hana' Mohammad Khair Ahmad Jaradat, Qosay Ali Elayyan Al-Balas, Nizar Ali Ahmad Al-Shar'I

22/06/2020
"Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking", Molecules

Suaad Abdallah Saleh Audat, Nizar Ali Ahmad Al-Shar'I, Buthina Abdallah Saleh Al-Oudat, Aref Louai Aref Zayed, Qosay Ali Elayyan Al-Balas

19/06/2020
"Identification of CHK1 Kinase Inhibitors Using Structure- Based Pharmacophore Modelling and Molecular Docking", Indian Journal of Pharmaceutical Sciences

Nizar Ali Ahmad Al-Shar'I, Sondos Sami Ahmad Khairy Musleh

02/05/2020
"Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold", Acta Pharmaceutica

Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Tamam Mohammad Murshed El-Elimat, Ammar Muntaser Habes Almaaytah

21/03/2020
"Discovery of a nanomolar glyoxalase-I inhibitor using integrated ligand-based pharmacophore modeling and molecular docking", Medicinal Chemistry Research

Nizar Ali Ahmad Al-Shar'I, Enas Khaled Saleh Al-Rousan, Lara Ishaq Issa Alfakhori, Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan

27/11/2019
"Discovery of a Nanomolar Inhibitor of the Human Glyoxalase-I Enzyme Using Structure-Based Poly-pharmacophore Modelling and Molecular Docking", Journal of Computer-Aided Molecular Design

Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas, Rand Ahed Mahmoud Al-Waqfi, Mohammad Abdelhafeez Abdelqader Hassan, Amer Ezzo Al Khalifa, Nehad M. M. Ayoub

21/09/2019
"Amino-carboxamide benzothiazoles as potential LSD1 hit inhibitors. Part I: Computational fragment-based drug design", Journal of Molecular Graphics and Modelling

Soraya Ma'Moun Othman Alnabulsi, Enas Adnan Salem Al-Hurani, Nizar Ali Ahmad Al-Shar'I, Tamam Mohammad Murshed El-Elimat

26/08/2019
"Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends", Current Pharmaceutical Design

Nizar Ali Ahmad Al-Shar'I, Qosay Ali Elayyan Al-Balas

26/02/2019
"Hit identification of SMYD3 enzyme inhibitors using structure-based pharmacophore modeling", Future Medicinal Chemsiitry

Soraya Ma'Moun Othman Alnabulsi, Nizar Ali Ahmad Al-Shar'I

07/02/2019
"Recent Advances in Glyoxalase-I Inhibition", Mini-Reviews in Medicinal Chemistry

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Nizar Ali Ahmad Al-Shar'I, Ghazi Ahmad Aljabal, Ammar Muntaser Habes Almaaytah

01/07/2018
"Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase-I inhibitors", Drug Development Research

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Nizar Ali Ahmad Al-Shar'I, Tamam Mohammad Murshed El-Elimat, Ammar Muntaser Habes Almaaytah

16/12/2017
"Experimental and Computational Comparative Study of the Supercritical Fluid Technology (SFT) and Kneading Method in Preparing ?-Cyclodextrin Complexes with Two Essential Oils (Linalool and Carvacrol)", AAPS PharmSciTech

Nizar Ali Ahmad Al-Shar'I, Rana Mohammed Khalid Obeidat

23/10/2017
"Novel Thiazole Carboxylic Acid Derivatives Possessing a ?Zinc Binding Feature? as Potential Human Glyoxalase-I Inhibitors", Letters in Drug Design & Discovery

Qosay Ali Elayyan Al-Balas, Mohammad Abdelhafeez Abdelqader Hassan, Ghazi Ahmad Aljabal, Nizar Ali Ahmad Al-Shar'I, Ammar Muntaser Habes Almaaytah, Tamam Mohammad Murshed El-Elimat

22/02/2017

Vice Dean, Vice dean, Sep 2020 - Sep 2021
Vice Dean, Vice dean, Sep 2019 - Sep 2020
Deputy Head of Department, Department of Medicinal Chemistry and Pharmacognosy, Sep 2017 - Sep 2018
Deputy Head of Department, Department of Medicinal Chemistry and Pharmacognosy, Sep 2014 - Sep 2017
Faculty Member, Department of Medicinal Chemistry and Pharmacognosy, Sep 2013 - Present
Assistant Dean, Assistant Dean, Sep 2013 - Sep 2014
Full-time Lecturer, Department of Medicinal Chemistry and Pharmacognosy, Apr 2013 - Sep 2013

Chair of pharmacy department, International academy for health sciences, Saudi Arabia, Mar 2007- Jul 2009

ADVANCED DRUG DESIGN
COMMUNITY PHARMACY (FOR PHARM.D STUDENTS)
MEDICINAL CHEMISTRY (1)
MEDICINAL CHEMISTRY (2)
MEDICINAL CHEMISTRY( 3)
MEDICINAL CHEMISTRY(2)
MOLECULAR MODELING AND COMPUTER-AIDED DRUG DESIGN
PHARMACEUTICAL PRACTICAL TRAINING
PHARMACEUTICAL ANALYTICAL CHEMISTRY & INSTRUMENTAL ANALYSIS LAB
RESEARCH METHODOLOGY
SELECTED TOPICS ( 1)
SELECTED TOPICS ( 2)
SEMINAR
SPECIAL TOPICS (A)

Conference Duties

Zarqa University Second Scientific Day, Jordan, Key Notes Speaker
Recent advances in pharmaceutical applications: a focus on vascular biology, Jordan, Co-Chair

Professional Memberships

Member in the Jordan Pharmaceutical Association, since January, 2002
Registered as a professional pharmacist from the Saudi Commission for Health Specialties, 2008