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Fresh pomegranate juice ameliorates insulin resistance, enhances beta-cell function, and decreases fasting serum glucose in type 2 diabetic patients
Although the effects of pomegranate juice (PJ) on type 2 diabetic (T2D) conditions have been reported a clinical study focusing on the short-term effects on different diabetic variables is still needed. We hypothesized that PJ consumption by T2D patients could reduce their insulin-resistant state and decrease their FSG levels, three hrs after juice ingestion. This study demonstrated the direct effect of fresh PJ on fasting serum glucose (FSG) and insulin levels in T2D patients. Blood samples from 85 participants with type 2 diabetes were collected after a 12-hr fast, then one and three hrs after administration of 1.5 mL of PJ, per kg body weight. Serum glucose was measured based on standard methods using the BS-200 Chemistry-Analyzer. Commercially available immunoassay kits were used to measure human insulin. Generally, the results demonstrated decreased FSG, increased β-cell function, and decreased insulin resistance among T2D participants, three hrs after PJ administration (P < 0.05). This hypoglycemic response depended on initial FSG levels, as participants with lower FSG levels (7.1- 8.7 mmol/L) demonstrated a greater hypoglycemic response (P < 0.05) compared with those that had higher FSG levels (8.8-15.8 mmol/L). The effect of PJ was also not affected by the gender of the patient and was less potent in elderly patients. In conclusion, this work offers some encouragement for T2D patients regarding PJ consumption as an additional contribution to control glucose levels.
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